Neoadjuvant chemotherapy with cef in locally advanced breast cancer
Home About MedWorm. Health News. Total neoadjuvant treatment in locally advanced rectal cancer Transl Oncol. Online ahead of print. ABSTRACTLocally advanced rectal cancer requires a multidisciplinary management, traditionally based on neo-adjuvant chemo radiotherapy, conservative surgery with total mesorectal excision and adjuvant chemotherapy. Here, we briefly assess the efficacy and discuss the clinical relevance of total neoadjuvant treatment with a focus on indications and results in the short-course radiotherapy followed by chemotherapy use for this setting of patients.
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Optimizing Neoadjuvant Therapy for Breast Cancer
Optimizing Neoadjuvant Therapy for Breast Cancer | MedPage Today
In some cases, treatment with chemotherapy, HER2-targeted therapy or hormone therapy may be given before breast surgery. Neoadjuvant therapy drugs are often the same as those used after surgery called adjuvant therapy. Before neoadjuvant therapy begins, you will have a needle biopsy to remove a small amount of tumor tissue. A radio-opaque clip is often placed in the tumor bed so the tumor can be found later when you have surgery. This clip is usually removed during the surgery. Tests on the biopsy tissue confirm your diagnosis and identify tumor characteristics, such as hormone receptor status and HER2 status. These factors determine the neoadjuvant therapy that will offer the most benefit.
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Low EC-pYFAK expression levels were found to be associated with chemotherapy sensitivity and improved 5-year relapse-free survival after systemic therapy in patients with neoadjuvant-treated locally advanced breast cancer. Findings from a study published in JAMA Network Open suggest that low endothelial cell phosphorylated—focal adhesion kinase EC-pYFAK expression levels are associated with chemotherapy sensitivity and improved 5-year relapse-free survival after systemic therapy in patients with neoadjuvant-treated locally advanced breast cancer. Overall, researchers indicated that this study highlights the potential clinical utility of EC-pYFAK expression levels in combination with blood vessel density BVD to guide therapeutic decision-making and testing of novel therapeutics in this high-risk group of patients. These data have potential therapeutic implications for high-risk populations that could benefit from additional novel therapy. In this prognostic study, researchers used immunohistochemistry in prechemotherapy core biopsies from 82 female patients with locally advanced breast cancer treated with anthracycline-based combination neoadjuvant chemotherapy at Nottingham City Hospital in Nottingham, UK to determine expression levels of EC-pYFAK and tumor cell TC -pYFA.
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